The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

Fic proteins are ubiquitous in all domains of life and play critical roles in multiple cellular processes through AMPylation of (transfer of AMP to) target proteins. Doc from the doc/phd toxin/antitoxin module is a member of the Fic family and inhibits bacterial translation by an unknown mechanism....

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Detalles Bibliográficos
Autores principales: Castro-Roa, Daniel, Garcia-Pino, Abel, De Gieter, Steven, van Nuland, Nico A.J., Loris, Remy, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836179/
https://www.ncbi.nlm.nih.gov/pubmed/24141193
http://dx.doi.org/10.1038/nchembio.1364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836179/
https://www.ncbi.nlm.nih.gov/pubmed/24141193
http://dx.doi.org/10.1038/nchembio.1364

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