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The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu
Fic proteins are ubiquitous in all domains of life and play critical roles in multiple cellular processes through AMPylation of (transfer of AMP to) target proteins. Doc from the doc/phd toxin/antitoxin module is a member of the Fic family and inhibits bacterial translation by an unknown mechanism....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836179/ https://www.ncbi.nlm.nih.gov/pubmed/24141193 http://dx.doi.org/10.1038/nchembio.1364 |