Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy

Although single gene loss of function analyses can identify components of particular processes, important molecules are missed due to the robustness of biological systems. Here we show that large scale RNAi screening for suppression interactions with functionally related mutants greatly expands the...

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Detalles Bibliográficos
Autores principales: Fievet, Bruno Thomas, Rodriguez, Josana, Naganathan, Sundar, Lee, Christine, Zeiser, Eva, Ishidate, Takao, Shirayama, Masaki, Grill, Stephan, Ahringer, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836181/
https://www.ncbi.nlm.nih.gov/pubmed/23242217
http://dx.doi.org/10.1038/ncb2639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836181/
https://www.ncbi.nlm.nih.gov/pubmed/23242217
http://dx.doi.org/10.1038/ncb2639

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