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HELQ promotes RAD51 paralog-dependent repair to avert germ cell attrition and tumourigenesis
Repair of interstrand crosslinks (ICLs) requires the coordinate action of the intra-S phase checkpoint and the Fanconi Anemia (FA) pathway, which promote ICL incision, translesion synthesis, and homologous recombination (reviewed in (1,2)). Previous studies have implicated the 3′-5′ superfamily 2 he...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836231/ https://www.ncbi.nlm.nih.gov/pubmed/24005329 http://dx.doi.org/10.1038/nature12565 |