HELQ promotes RAD51 paralog-dependent repair to avert germ cell attrition and tumourigenesis

Repair of interstrand crosslinks (ICLs) requires the coordinate action of the intra-S phase checkpoint and the Fanconi Anemia (FA) pathway, which promote ICL incision, translesion synthesis, and homologous recombination (reviewed in (1,2)). Previous studies have implicated the 3′-5′ superfamily 2 he...

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Detalles Bibliográficos
Autores principales: Adelman, Carrie A., Lolo, Rafal L., Birkbak, Nicolai J., Murina, Olga, Matsuzaki, Kenichiro, Horejsi, Zuzana, Parmar, Kalindi, Borel, Valérie, Skehel, J. Mark, Stamp, Gordon, D’Andrea, Alan, Sartori, Alessandro A., Swanton, Charles, Boulton, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836231/
https://www.ncbi.nlm.nih.gov/pubmed/24005329
http://dx.doi.org/10.1038/nature12565

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