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miRNAs confer phenotypic robustness to gene networks by suppressing biological noise
miRNAs are small non-coding RNAs able to modulate target-gene expression. It has been postulated that miRNAs confer robustness to biological processes, but a clear experimental evidence is still missing. Using a synthetic biology approach, we demonstrate that microRNAs provide phenotypic robustness...
Autores principales: | Siciliano, Velia, Garzilli, Immacolata, Fracassi, Chiara, Criscuolo, Stefania, Ventre, Simona, di Bernardo, Diego |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836244/ https://www.ncbi.nlm.nih.gov/pubmed/24077216 http://dx.doi.org/10.1038/ncomms3364 |
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