Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway

The neurotoxicity of amyloid-β (Aβ) has been implicated as a critical cause of Alzheimer's disease. Isorhynchophylline (IRN), an oxindole alkaloid isolated from Uncaria rhynchophylla, exerts neuroprotective effect against Aβ (25–35)-induced neurotoxicity in vitro. However, the exact mechanism f...

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Detalles Bibliográficos
Autores principales: Xian, Yan-Fang, Lin, Zhi-Xiu, Mao, Qing-Qiu, Chen, Jian-Nan, Su, Zi-Ren, Lai, Xiao-Ping, Ip, Paul Siu-Po
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836301/
https://www.ncbi.nlm.nih.gov/pubmed/24319473
http://dx.doi.org/10.1155/2013/163057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836301/
https://www.ncbi.nlm.nih.gov/pubmed/24319473
http://dx.doi.org/10.1155/2013/163057

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