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Identification of Key Hinge Residues Important for Nucleotide-Dependent Allostery in E. coli Hsp70/DnaK

DnaK is a molecular chaperone that has important roles in protein folding. The hydrolysis of ATP is essential to this activity, and the effects of nucleotides on the structure and function of DnaK have been extensively studied. However, the key residues that govern the conformational motions that de...

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Detalles Bibliográficos
Autores principales: Ung, Peter Man-Un, Thompson, Andrea D., Chang, Lyra, Gestwicki, Jason E., Carlson, Heather A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836694/
https://www.ncbi.nlm.nih.gov/pubmed/24277995
http://dx.doi.org/10.1371/journal.pcbi.1003279