DUX4 Binding to Retroelements Creates Promoters That Are Active in FSHD Muscle and Testis

The human double-homeodomain retrogene DUX4 is expressed in the testis and epigenetically repressed in somatic tissues. Facioscapulohumeral muscular dystrophy (FSHD) is caused by mutations that decrease the epigenetic repression of DUX4 in somatic tissues and result in mis-expression of this transcr...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, Janet M., Whiddon, Jennifer L., Yao, Zizhen, Kasinathan, Bhavatharini, Snider, Lauren, Geng, Linda N., Balog, Judit, Tawil, Rabi, van der Maarel, Silvère M., Tapscott, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836709/
https://www.ncbi.nlm.nih.gov/pubmed/24278031
http://dx.doi.org/10.1371/journal.pgen.1003947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836709/
https://www.ncbi.nlm.nih.gov/pubmed/24278031
http://dx.doi.org/10.1371/journal.pgen.1003947

Ejemplares similares