Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases

The Kaposi's sarcoma-associated herpesvirus gene products K3 and K5 are viral ubiquitin E3 ligases which downregulate MHC-I and additional cell surface immunoreceptors. To identify novel cellular genes required for K5 function we performed a forward genetic screen in near-haploid human KBM7 cel...

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Detalles Bibliográficos
Autores principales: Timms, Richard T., Duncan, Lidia M., Tchasovnikarova, Iva A., Antrobus, Robin, Smith, Duncan L., Dougan, Gordon, Weekes, Michael P., Lehner, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836740/
https://www.ncbi.nlm.nih.gov/pubmed/24278019
http://dx.doi.org/10.1371/journal.ppat.1003772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836740/
https://www.ncbi.nlm.nih.gov/pubmed/24278019
http://dx.doi.org/10.1371/journal.ppat.1003772

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