A Novel Antibody Humanization Method Based on Epitopes Scanning and Molecular Dynamics Simulation

1-17-2 is a rat anti-human DEC-205 monoclonal antibody that induces internalization and delivers antigen to dendritic cells (DCs). The potentially clinical application of this antibody is limited by its murine origin. Traditional humanization method such as complementarity determining regions (CDRs)...

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Detalles Bibliográficos
Autores principales: Zhang, Ding, Chen, Cai-Feng, Zhao, Bin-Bin, Gong, Lu-Lu, Jin, Wen-Jing, Liu, Jing-Jun, Wang, Jing-Fei, Wang, Tian-Tian, Yuan, Xiao-Hui, He, You-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836750/
https://www.ncbi.nlm.nih.gov/pubmed/24278299
http://dx.doi.org/10.1371/journal.pone.0080636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836750/
https://www.ncbi.nlm.nih.gov/pubmed/24278299
http://dx.doi.org/10.1371/journal.pone.0080636

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