Quantitative Identification of Mutant Alleles Derived from Lung Cancer in Plasma Cell-Free DNA via Anomaly Detection Using Deep Sequencing Data

The detection of rare mutants using next generation sequencing has considerable potential for diagnostic applications. Detecting circulating tumor DNA is the foremost application of this approach. The major obstacle to its use is the high read error rate of next-generation sequencers. Rather than in...

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Detalles Bibliográficos
Autores principales: Kukita, Yoji, Uchida, Junji, Oba, Shigeyuki, Nishino, Kazumi, Kumagai, Toru, Taniguchi, Kazuya, Okuyama, Takako, Imamura, Fumio, Kato, Kikuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836767/
https://www.ncbi.nlm.nih.gov/pubmed/24278442
http://dx.doi.org/10.1371/journal.pone.0081468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836767/
https://www.ncbi.nlm.nih.gov/pubmed/24278442
http://dx.doi.org/10.1371/journal.pone.0081468

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