Genetic and Functional Studies Implicate Synaptic Overgrowth and Ring Gland cAMP/PKA Signaling Defects in the Drosophila melanogaster Neurofibromatosis-1 Growth Deficiency

Neurofibromatosis type 1 (NF1), a genetic disease that affects 1 in 3,000, is caused by loss of a large evolutionary conserved protein that serves as a GTPase Activating Protein (GAP) for Ras. Among Drosophila melanogaster Nf1 (dNf1) null mutant phenotypes, learning/memory deficits and reduced overa...

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Detalles Bibliográficos
Autores principales: Walker, James A., Gouzi, Jean Y., Long, Jennifer B., Huang, Sidong, Maher, Robert C., Xia, Hongjing, Khalil, Kheyal, Ray, Arjun, Van Vactor, David, Bernards, René, Bernards, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836801/
https://www.ncbi.nlm.nih.gov/pubmed/24278035
http://dx.doi.org/10.1371/journal.pgen.1003958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836801/
https://www.ncbi.nlm.nih.gov/pubmed/24278035
http://dx.doi.org/10.1371/journal.pgen.1003958

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