Na(+)/H(+) Exchangers Induce Autophagy in Neurons and Inhibit Polyglutamine-Induced Aggregate Formation

In polyglutamine diseases, an abnormally elongated polyglutamine results in protein misfolding and accumulation of intracellular aggregates. Autophagy is a major cellular degradative pathway responsible for eliminating unnecessary proteins, including polyglutamine aggregates. Basal autophagy constit...

Descripción completa

Detalles Bibliográficos
Autores principales: Togashi, Kazuya, Wakatsuki, Shuji, Furuno, Akiko, Tokunaga, Shinji, Nagai, Yoshitaka, Araki, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836979/
https://www.ncbi.nlm.nih.gov/pubmed/24278418
http://dx.doi.org/10.1371/journal.pone.0081313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836979/
https://www.ncbi.nlm.nih.gov/pubmed/24278418
http://dx.doi.org/10.1371/journal.pone.0081313

Ejemplares similares