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Na(+)/H(+) Exchangers Induce Autophagy in Neurons and Inhibit Polyglutamine-Induced Aggregate Formation
In polyglutamine diseases, an abnormally elongated polyglutamine results in protein misfolding and accumulation of intracellular aggregates. Autophagy is a major cellular degradative pathway responsible for eliminating unnecessary proteins, including polyglutamine aggregates. Basal autophagy constit...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836979/ https://www.ncbi.nlm.nih.gov/pubmed/24278418 http://dx.doi.org/10.1371/journal.pone.0081313 |