Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease

Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mouse models. Genetic or pharmacologic inhibition of hepatic Notch signaling in obese mice simultaneously improves glucose tolerance and reduces hepatic triglyceride content. As such, we predicted that Notch signaling in...

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Detalles Bibliográficos
Autores principales: Valenti, Luca, Mendoza, Rosa M., Rametta, Raffaela, Maggioni, Marco, Kitajewski, Chris, Shawber, Carrie J., Pajvani, Utpal B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837035/
https://www.ncbi.nlm.nih.gov/pubmed/23990360
http://dx.doi.org/10.2337/db13-0769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837035/
https://www.ncbi.nlm.nih.gov/pubmed/23990360
http://dx.doi.org/10.2337/db13-0769

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