Cargando…
Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease
Hepatic Notch signaling is inappropriately activated in obese/insulin-resistant mouse models. Genetic or pharmacologic inhibition of hepatic Notch signaling in obese mice simultaneously improves glucose tolerance and reduces hepatic triglyceride content. As such, we predicted that Notch signaling in...
Autores principales: | Valenti, Luca, Mendoza, Rosa M., Rametta, Raffaela, Maggioni, Marco, Kitajewski, Chris, Shawber, Carrie J., Pajvani, Utpal B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837035/ https://www.ncbi.nlm.nih.gov/pubmed/23990360 http://dx.doi.org/10.2337/db13-0769 |
Ejemplares similares
-
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner
por: Pajvani, Utpal B., et al.
Publicado: (2011) -
Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
por: Kim, KyeongJin, et al.
Publicado: (2021) -
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
por: Pajvani, Utpal B., et al.
Publicado: (2013) -
The A736V TMPRSS6 Polymorphism Influences Hepatic Iron Overload in Nonalcoholic Fatty Liver Disease
por: Valenti, Luca, et al.
Publicado: (2012) -
Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus
por: Shawber, Carrie J., et al.
Publicado: (2015)