Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5′-Triphosphate Cyclohydrolase 1 Instigate Its Ubiquitination in Diabetes

Aberrant degradation of guanosine 5′-triphosphate cyclohydrolase 1 (GTPCH1) with consequent deficiency of tetrahydrobiopterin is considered the primary cause for endothelial dysfunction in diabetes. How GTPCH1 becomes susceptible to the degradation remains unknown. We hypothesized that oxidation and...

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Detalles Bibliográficos
Autores principales: Zhao, Yu, Wu, Jiliang, Zhu, Huaiping, Song, Ping, Zou, Ming-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837037/
https://www.ncbi.nlm.nih.gov/pubmed/23974923
http://dx.doi.org/10.2337/db13-0751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837037/
https://www.ncbi.nlm.nih.gov/pubmed/23974923
http://dx.doi.org/10.2337/db13-0751

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