Diminished Adenosine A1 Receptor Expression in Pancreatic α-Cells May Contribute to the Pathology of Type 1 Diabetes

Prediabetic NOD mice exhibit hyperglucagonemia, possibly due to an intrinsic α-cell defect. Here, we show that the expression of a potential glucagon inhibitor, the adenosine A1 receptor (Adora1), is gradually diminished in α-cells of NOD mice, autoantibody-positive (AA(+)) and overtly type 1 diabet...

Descripción completa

Detalles Bibliográficos
Autores principales: Yip, Linda, Taylor, Cariel, Whiting, Chan C., Fathman, C. Garrison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837064/
https://www.ncbi.nlm.nih.gov/pubmed/24264405
http://dx.doi.org/10.2337/db13-0614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837064/
https://www.ncbi.nlm.nih.gov/pubmed/24264405
http://dx.doi.org/10.2337/db13-0614

Ejemplares similares