TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway

In the current study, we investigated the role of tribbles homolog 3 (TRIB3) in glucose-induced insulin resistance and whether the induction of TRIB3 by glucose is dependent on the nutrient-sensing hexosamine biosynthetic pathway (HBP) known to mediate glucose toxicity in diabetes. In diabetic rats,...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Liu, Jiarong, Tian, Ling, Liu, Qinglan, Fu, Yuchang, Garvey, W. Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837074/
https://www.ncbi.nlm.nih.gov/pubmed/23990361
http://dx.doi.org/10.2337/db13-0312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837074/
https://www.ncbi.nlm.nih.gov/pubmed/23990361
http://dx.doi.org/10.2337/db13-0312

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