Cargando…

TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway

In the current study, we investigated the role of tribbles homolog 3 (TRIB3) in glucose-induced insulin resistance and whether the induction of TRIB3 by glucose is dependent on the nutrient-sensing hexosamine biosynthetic pathway (HBP) known to mediate glucose toxicity in diabetes. In diabetic rats,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wei, Liu, Jiarong, Tian, Ling, Liu, Qinglan, Fu, Yuchang, Garvey, W. Timothy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837074/ https://www.ncbi.nlm.nih.gov/pubmed/23990361 http://dx.doi.org/10.2337/db13-0312

Ejemplares similares

Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance
por: Zhang, Wei, et al.
Publicado: (2016)

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer
por: Akella, Neha M., et al.
Publicado: (2019)

The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology
por: Cairns, Megan, et al.
Publicado: (2022)

Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
por: Kaushik, Akash K., et al.
Publicado: (2016)

Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes
por: Taparra, Kekoa, et al.
Publicado: (2016)

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways
por: Ryczko, Michael C., et al.
Publicado: (2016)

Differential hexosamine biosynthetic pathway gene expression with type 2 diabetes
por: Coomer, Megan, et al.
Publicado: (2014)

The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring
por: Chiaradonna, Ferdinando, et al.
Publicado: (2018)

Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells
por: de Queiroz, Rafaela Muniz, et al.
Publicado: (2019)

Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway
por: Vasconcelos-dos-Santos, A, et al.
Publicado: (2017)

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway
por: Chaveroux, Cédric, et al.
Publicado: (2016)

Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions
por: Lin, Shu-Hai, et al.
Publicado: (2016)

Glycolysis and the Hexosamine Biosynthetic Pathway as Novel Targets for Upper and Lower Airway Inflammation
por: Kim, Young Hyo, et al.
Publicado: (2018)

Roles of the hexosamine biosynthetic pathway and pentose phosphate pathway in bile acid‐induced cancer development
por: Munemoto, Masayoshi, et al.
Publicado: (2019)

The Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling
por: Brasier, Allan R., et al.
Publicado: (2021)

Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit
por: Wang, Yixin, et al.
Publicado: (2023)

O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance
por: Liu, Yubo, et al.
Publicado: (2018)

Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host
por: Gomes, Pollyanna Stephanie, et al.
Publicado: (2019)

Hexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation
por: Kim, Myoung Jun, et al.
Publicado: (2021)

Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation Via Hexosamine Biosynthetic Pathway
por: Grilo, Luís F., et al.
Publicado: (2023)

Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
por: Gitenay, D, et al.
Publicado: (2014)

Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
por: Gitenay, D, et al.
Publicado: (2014)

Glutamine is a substrate for glycosylation and CA19-9 biosynthesis through hexosamine biosynthetic pathway in pancreatic cancer
por: Liu, Chen, et al.
Publicado: (2023)

Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis
por: Ricciardiello, Francesca, et al.
Publicado: (2018)

Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling
por: Cork, Gentry K., et al.
Publicado: (2018)

Tisp40 prevents cardiac ischemia/reperfusion injury through the hexosamine biosynthetic pathway in male mice
por: Zhang, Xin, et al.
Publicado: (2023)

Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation
por: Liu, Xianhui, et al.
Publicado: (2021)

The Hexosamine Biosynthesis Pathway: Regulation and Function
por: Paneque, Alysta, et al.
Publicado: (2023)

Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1α-XBP1s arm of the unfolded protein response
por: Qiao, Dianhua, et al.
Publicado: (2021)

Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression
por: Saeed, Muhammad Tariq, et al.
Publicado: (2016)

RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection
por: Xu, Xiaofang, et al.
Publicado: (2022)

Increased hexosamine biosynthetic pathway flux alters cell–cell adhesion in INS-1E cells and murine islets
por: Lofrumento, Dario Domenico, et al.
Publicado: (2023)

Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway
por: Jiang, Bo, et al.
Publicado: (2015)

A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1
por: Chen, Xiping, et al.
Publicado: (2020)

Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma
por: Pham, Lan V., et al.
Publicado: (2016)

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway
por: Panarsky, Rony, et al.
Publicado: (2020)

Stomatin-like protein 2 induces metastasis by regulating the expression of a rate-limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer
por: Chao, Dang, et al.
Publicado: (2021)

Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer
por: Zou, Yi, et al.
Publicado: (2023)

Prognostic relevance of the hexosamine biosynthesis pathway activation in leiomyosarcoma
por: Tolwani, Angela, et al.
Publicado: (2021)

Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation
por: Hu, Jie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3bfac0pr4orortm1b4a5q0vuo1