Molecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure: Discovery of a Novel DNMT1 Inhibitor

DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel anticancer drugs and other diseases. Molecular modeling and experimental approaches are being used to identify and develop inhibitors of human DNMTs. Most of the computational efforts conducted so far with D...

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Detalles Bibliográficos
Autores principales: Yoo, Jakyung, Kim, Joo Hee, Robertson, Keith D., Medina-Franco, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837394/
https://www.ncbi.nlm.nih.gov/pubmed/22607757
http://dx.doi.org/10.1016/B978-0-12-398312-1.00008-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837394/
https://www.ncbi.nlm.nih.gov/pubmed/22607757
http://dx.doi.org/10.1016/B978-0-12-398312-1.00008-1

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