A suppressor screen in mouse Mecp2 implicates cholesterol metabolism in Rett Syndrome

Mutations in methyl CpG binding protein 2 (MECP2) cause Rett Syndrome, the most severe autism spectrum disorder. Re-expressing Mecp2 in symptomatic Mecp2 null mice dramatically improves function and longevity, providing hope that therapeutic intervention is possible in humans. To identify pathways i...

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Detalles Bibliográficos
Autores principales: Buchovecky, Christie M., Turley, Stephen D., Brown, Hannah M., Kyle, Stephanie M., McDonald, Jeffrey G., Liu, Benny, Pieper, Andrew A., Huang, Wenhui, Katz, David M., Russell, David W., Shendure, Jay, Justice, Monica J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837522/
https://www.ncbi.nlm.nih.gov/pubmed/23892605
http://dx.doi.org/10.1038/ng.2714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837522/
https://www.ncbi.nlm.nih.gov/pubmed/23892605
http://dx.doi.org/10.1038/ng.2714

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