The USP21 Short Variant (USP21SV) Lacking NES, Located Mostly in the Nucleus In Vivo, Activates Transcription by Deubiquitylating ubH2A In Vitro

USP21 is a deubiquitylase that catalyzes isopeptide bond hydrolysis between ubiquitin and histone H2A. Since ubiqutylated H2A (ubH2A) represses transcription, USP21 plays a role in transcriptional activation. On the other hand, the localization of USP21 suggests it has an additional function in the...

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Detalles Bibliográficos
Autores principales: Okuda, Hiroshi, Ohdan, Hideki, Nakayama, Manabu, Koseki, Haruhiko, Nakagawa, Takeya, Ito, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838379/
https://www.ncbi.nlm.nih.gov/pubmed/24278184
http://dx.doi.org/10.1371/journal.pone.0079813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838379/
https://www.ncbi.nlm.nih.gov/pubmed/24278184
http://dx.doi.org/10.1371/journal.pone.0079813

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