Streptococcal SpeB Cleaved PAR-1 Suppresses ERK Phosphorylation and Blunts Thrombin-Induced Platelet Aggregation

BACKGROUND: The family of 4 related protease-activated receptors (PAR-1, 2, 3 & 4) expressed by mammalian cells allow to sense for and react to extracellular proteolytic activity. Since major human bacterial pathogens secret a wide array of protease(-s) we investigated whether they interfere wit...

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Detalles Bibliográficos
Autores principales: Ender, Miriam, Andreoni, Federica, Zinkernagel, Annelies Sophie, Schuepbach, Reto Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838405/
https://www.ncbi.nlm.nih.gov/pubmed/24278414
http://dx.doi.org/10.1371/journal.pone.0081298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838405/
https://www.ncbi.nlm.nih.gov/pubmed/24278414
http://dx.doi.org/10.1371/journal.pone.0081298

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