Extended Duration of Transgene Expression from Pegylated POD Nanoparticles Enables Attenuation of Photoreceptor Degeneration

Retinitis pigmentosa (RP) is the most genetically heterogeneous disorder known to cause blindness, involving over 50 different genes. Previously, we have described nanoparticles (NPs) 150 nm in size, comprised of a 3.5 kD peptide (POD) complexed to PEG and DNA (PEGPOD DNA). These NPs expressing GDNF...

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Detalles Bibliográficos
Autores principales: Binder, Christina, Cashman, Siobhan M., Kumar-Singh, Rajendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838409/
https://www.ncbi.nlm.nih.gov/pubmed/24278479
http://dx.doi.org/10.1371/journal.pone.0082295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838409/
https://www.ncbi.nlm.nih.gov/pubmed/24278479
http://dx.doi.org/10.1371/journal.pone.0082295

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