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The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach

Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population usin...

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Autores principales: McGlinchey, Paul G., Spence, Mark S., Patterson, Chris C., Allen, Adrian R., Murphy, Gillian, Fogarty, Damian, Evans, Alun, McKeown, Pascal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839324/
https://www.ncbi.nlm.nih.gov/pubmed/15665388
http://dx.doi.org/10.1155/2004/715745
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author McGlinchey, Paul G.
Spence, Mark S.
Patterson, Chris C.
Allen, Adrian R.
Murphy, Gillian
Fogarty, Damian
Evans, Alun
McKeown, Pascal P.
author_facet McGlinchey, Paul G.
Spence, Mark S.
Patterson, Chris C.
Allen, Adrian R.
Murphy, Gillian
Fogarty, Damian
Evans, Alun
McKeown, Pascal P.
author_sort McGlinchey, Paul G.
collection PubMed
description Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD.
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spelling pubmed-38393242013-12-17 The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach McGlinchey, Paul G. Spence, Mark S. Patterson, Chris C. Allen, Adrian R. Murphy, Gillian Fogarty, Damian Evans, Alun McKeown, Pascal P. Dis Markers Other Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD. IOS Press 2004 2005-01-18 /pmc/articles/PMC3839324/ /pubmed/15665388 http://dx.doi.org/10.1155/2004/715745 Text en Copyright © 2004 Hindawi Publishing Corporation.
spellingShingle Other
McGlinchey, Paul G.
Spence, Mark S.
Patterson, Chris C.
Allen, Adrian R.
Murphy, Gillian
Fogarty, Damian
Evans, Alun
McKeown, Pascal P.
The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_full The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_fullStr The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_full_unstemmed The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_short The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_sort matrix metalloproteinase-3 (mmp-3) 5a/6a promoter polymorphism is not associated with ischaemic heart disease: analysis employing a family based approach
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839324/
https://www.ncbi.nlm.nih.gov/pubmed/15665388
http://dx.doi.org/10.1155/2004/715745
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