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The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population usin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839324/ https://www.ncbi.nlm.nih.gov/pubmed/15665388 http://dx.doi.org/10.1155/2004/715745 |
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author | McGlinchey, Paul G. Spence, Mark S. Patterson, Chris C. Allen, Adrian R. Murphy, Gillian Fogarty, Damian Evans, Alun McKeown, Pascal P. |
author_facet | McGlinchey, Paul G. Spence, Mark S. Patterson, Chris C. Allen, Adrian R. Murphy, Gillian Fogarty, Damian Evans, Alun McKeown, Pascal P. |
author_sort | McGlinchey, Paul G. |
collection | PubMed |
description | Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD. |
format | Online Article Text |
id | pubmed-3839324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38393242013-12-17 The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach McGlinchey, Paul G. Spence, Mark S. Patterson, Chris C. Allen, Adrian R. Murphy, Gillian Fogarty, Damian Evans, Alun McKeown, Pascal P. Dis Markers Other Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD. IOS Press 2004 2005-01-18 /pmc/articles/PMC3839324/ /pubmed/15665388 http://dx.doi.org/10.1155/2004/715745 Text en Copyright © 2004 Hindawi Publishing Corporation. |
spellingShingle | Other McGlinchey, Paul G. Spence, Mark S. Patterson, Chris C. Allen, Adrian R. Murphy, Gillian Fogarty, Damian Evans, Alun McKeown, Pascal P. The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach |
title | The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach |
title_full | The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach |
title_fullStr | The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach |
title_full_unstemmed | The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach |
title_short | The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach |
title_sort | matrix metalloproteinase-3 (mmp-3) 5a/6a promoter polymorphism is not associated with ischaemic heart disease: analysis employing a family based approach |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839324/ https://www.ncbi.nlm.nih.gov/pubmed/15665388 http://dx.doi.org/10.1155/2004/715745 |
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