p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation

Myocardial infarction, an irreversible cardiac tissue damage, involves progressive loss of cardiomyocytes due to p53-mediated apoptosis. Oxygenation is known to promote cardiac survival through activation of NOS3 gene. We hypothesized a dual role for p53, which, depending on oxygenation, can elicit...

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Detalles Bibliográficos
Autores principales: Gogna, Rajan, Madan, Esha, Khan, Mahmood, Pati, Uttam, Kuppusamy, Periannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840484/
https://www.ncbi.nlm.nih.gov/pubmed/24096875
http://dx.doi.org/10.1002/emmm.201202055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840484/
https://www.ncbi.nlm.nih.gov/pubmed/24096875
http://dx.doi.org/10.1002/emmm.201202055

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