A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models

BACKGROUND: Transcription activator-like effector nucleases (TALENs) have emerged as a tool for enabling targeted gene editing and disruption in difficult systems, such as human pluripotent stem cells (hPSCs). The modular architecture of TAL effectors theoretically enables targeting of any genomic l...

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Detalles Bibliográficos
Autores principales: Frank, Stefan, Skryabin, Boris V, Greber, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840567/
https://www.ncbi.nlm.nih.gov/pubmed/24206569
http://dx.doi.org/10.1186/1471-2164-14-773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840567/
https://www.ncbi.nlm.nih.gov/pubmed/24206569
http://dx.doi.org/10.1186/1471-2164-14-773

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