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A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models
BACKGROUND: Transcription activator-like effector nucleases (TALENs) have emerged as a tool for enabling targeted gene editing and disruption in difficult systems, such as human pluripotent stem cells (hPSCs). The modular architecture of TAL effectors theoretically enables targeting of any genomic l...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840567/ https://www.ncbi.nlm.nih.gov/pubmed/24206569 http://dx.doi.org/10.1186/1471-2164-14-773 |