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Role of IGF-1 pathway in lung fibroblast activation

BACKGROUND: IGF-1 is elevated in pulmonary fibrosis and acute lung injury, where fibroblast activation is a prominent feature. We previously demonstrated that blockade of IGF pathway in murine model of lung fibrosis improved outcome and decreased fibrosis. We now expand that study to examine effects...

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Detalles Bibliográficos
Autores principales: Hung, Chi F, Rohani, Maryam G, Lee, Sung-soon, Chen, Peter, Schnapp, Lynn M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840605/
https://www.ncbi.nlm.nih.gov/pubmed/24103846
http://dx.doi.org/10.1186/1465-9921-14-102