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CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Glioblastoma multiforme (GBM) comprises several molecular subtypes including proneural GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy is to target cells in the glioma microenvironment, such as tumor-associated macrophages and microglia (TAMs). Macrophage...
Autores principales: | Pyonteck, Stephanie M., Akkari, Leila, Schuhmacher, Alberto J., Bowman, Robert L., Sevenich, Lisa, Quail, Daniela F., Olson, Oakley C., Quick, Marsha L., Huse, Jason T., Teijeiro, Virginia, Setty, Manu, Leslie, Christina S., Oei, Yoko, Pedraza, Alicia, Zhang, Jianan, Brennan, Cameron W., Sutton, James C., Holland, Eric C., Daniel, Dylan, Joyce, Johanna A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840724/ https://www.ncbi.nlm.nih.gov/pubmed/24056773 http://dx.doi.org/10.1038/nm.3337 |
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