Cargando…

Engineering Folding Dynamics from Two-State to Downhill: Application to λ-Repressor

[Image: see text] One strategy for reaching the downhill folding regime, primarily exploited for the λ(6–85) protein fragment, consists of cumulatively introducing mutations that speed up folding. This is an experimentally demanding process where chemical intuition usually serves as a guide for the...

Descripción completa

Detalles Bibliográficos
Autores principales: Carter, James W., Baker, Christopher M., Best, Robert B., De Sancho, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840902/
https://www.ncbi.nlm.nih.gov/pubmed/24079652
http://dx.doi.org/10.1021/jp405904g