Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition

TOR (target of rapamycin) signaling coordinates cell growth, metabolism, and cell division through tight control of signaling via two complexes, TORC1 and TORC2. Here, we show that fission yeast TOR kinases and mTOR are phosphorylated on an evolutionarily conserved residue of their ATP-binding domai...

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Detalles Bibliográficos
Autores principales: Hálová, Lenka, Du, Wei, Kirkham, Sara, Smith, Duncan L., Petersen, Janni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840928/
https://www.ncbi.nlm.nih.gov/pubmed/24247430
http://dx.doi.org/10.1083/jcb.201305103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840928/
https://www.ncbi.nlm.nih.gov/pubmed/24247430
http://dx.doi.org/10.1083/jcb.201305103

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