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Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition
TOR (target of rapamycin) signaling coordinates cell growth, metabolism, and cell division through tight control of signaling via two complexes, TORC1 and TORC2. Here, we show that fission yeast TOR kinases and mTOR are phosphorylated on an evolutionarily conserved residue of their ATP-binding domai...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840928/ https://www.ncbi.nlm.nih.gov/pubmed/24247430 http://dx.doi.org/10.1083/jcb.201305103 |