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An internal ligand-bound, metastable state of a leukocyte integrin, α(X)β(2)
How is massive conformational change in integrins achieved on a rapid timescale? We report crystal structures of a metastable, putative transition state of integrin α(X)β(2). The α(X)β(2) ectodomain is bent; however, a lattice contact stabilizes its ligand-binding αI domain in a high affinity, open...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840939/ https://www.ncbi.nlm.nih.gov/pubmed/24385486 http://dx.doi.org/10.1083/jcb.201308083 |