HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration

Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused by an aggregation-prone polyglutamine expans...

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Detalles Bibliográficos
Autores principales: Mielcarek, Michal, Landles, Christian, Weiss, Andreas, Bradaia, Amyaouch, Seredenina, Tamara, Inuabasi, Linda, Osborne, Georgina F., Wadel, Kristian, Touller, Chrystelle, Butler, Rachel, Robertson, Janette, Franklin, Sophie A., Smith, Donna L., Park, Larry, Marks, Paul A., Wanker, Erich E., Olson, Eric N., Luthi-Carter, Ruth, van der Putten, Herman, Beaumont, Vahri, Bates, Gillian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841096/
https://www.ncbi.nlm.nih.gov/pubmed/24302884
http://dx.doi.org/10.1371/journal.pbio.1001717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841096/
https://www.ncbi.nlm.nih.gov/pubmed/24302884
http://dx.doi.org/10.1371/journal.pbio.1001717

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