Changes in the Expression of miR-381 and miR-495 Are Inversely Associated with the Expression of the MDR1 Gene and Development of Multi-Drug Resistance

Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump to reduce the intracellular concentration of the drug(s). Thus, inhibiting P-gp expression mi...

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Detalles Bibliográficos
Autores principales: Xu, Yan, Ohms, Stephen J., Li, Zhen, Wang, Qiao, Gong, Guangming, Hu, Yiqiao, Mao, Zhiyong, Shannon, M. Frances, Fan, Jun Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841137/
https://www.ncbi.nlm.nih.gov/pubmed/24303078
http://dx.doi.org/10.1371/journal.pone.0082062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841137/
https://www.ncbi.nlm.nih.gov/pubmed/24303078
http://dx.doi.org/10.1371/journal.pone.0082062

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