Effect of Calstabin1 Depletion on Calcium Transients and Energy Utilization in Muscle Fibers and Treatment Opportunities with RyR1 Stabilizers

Depletion of calstabin1 (FKBP12) from the RyR1 channel and consequential calcium leakage from the sarcoplasmic reticulum (SR) is found in certain disease conditions such as dystrophy, aging or muscle overuse. Here, we first assessed the effect of calstabin1 depletion on resting Ca(2+) levels and tra...

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Detalles Bibliográficos
Autores principales: Breckner, Anke, Ganz, Magdalena, Marcellin, David, Richter, Jens, Gerwin, Nicole, Rausch, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841141/
https://www.ncbi.nlm.nih.gov/pubmed/24303040
http://dx.doi.org/10.1371/journal.pone.0081277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841141/
https://www.ncbi.nlm.nih.gov/pubmed/24303040
http://dx.doi.org/10.1371/journal.pone.0081277

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