Ubiquitin Ligase HUWE1 Regulates Axon Branching through the Wnt/β-Catenin Pathway in a Drosophila Model for Intellectual Disability

We recently reported that duplication of the E3 ubiquitin ligase HUWE1 results in intellectual disability (ID) in male patients. However, the underlying molecular mechanism remains unknown. We used Drosophila melanogaster as a model to investigate the effect of increased HUWE1 levels on the developi...

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Detalles Bibliográficos
Autores principales: Vandewalle, Joke, Langen, Marion, Zschaetzsch, Marlen, Nijhof, Bonnie, Kramer, Jamie M., Brems, Hilde, Bauters, Marijke, Lauwers, Elsa, Srahna, Mohammed, Marynen, Peter, Verstreken, Patrik, Schenck, Annette, Hassan, Bassem A., Froyen, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841167/
https://www.ncbi.nlm.nih.gov/pubmed/24303071
http://dx.doi.org/10.1371/journal.pone.0081791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841167/
https://www.ncbi.nlm.nih.gov/pubmed/24303071
http://dx.doi.org/10.1371/journal.pone.0081791

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