α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes

Mutation of the adenomatous polyposis coli (APC) tumor suppressor stabilizes β-catenin and aberrantly reactivates Wnt/β-catenin target genes in colon cancer. APC mutants in cancer frequently lack the conserved catenin inhibitory domain (CID), which is essential for β-catenin proteolysis. Here we sho...

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Detalles Bibliográficos
Autores principales: Choi, Seung H., Estarás, Conchi, Moresco, James J., Yates, John R., Jones, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841736/
https://www.ncbi.nlm.nih.gov/pubmed/24240237
http://dx.doi.org/10.1101/gad.229062.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841736/
https://www.ncbi.nlm.nih.gov/pubmed/24240237
http://dx.doi.org/10.1101/gad.229062.113

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