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Nucleotide-induced asymmetry within ATPase activator ring drives σ54–RNAP interaction and ATP hydrolysis

It is largely unknown how the typical homomeric ring geometry of ATPases associated with various cellular activities enables them to perform mechanical work. Small-angle solution X-ray scattering, crystallography, and electron microscopy (EM) reconstructions revealed that partial ATP occupancy cause...

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Detalles Bibliográficos
Autores principales: Sysoeva, Tatyana A., Chowdhury, Saikat, Guo, Liang, Nixon, B. Tracy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841738/
https://www.ncbi.nlm.nih.gov/pubmed/24240239
http://dx.doi.org/10.1101/gad.229385.113