Redox environment is an intracellular factor to operate distinct pathways for aggregation of Cu,Zn-superoxide dismutase in amyotrophic lateral sclerosis

Dominant mutations in Cu,Zn-superoxide dismutase (SOD1) cause a familial form of amyotrophic lateral sclerosis (fALS). Misfolding and aggregation of mutant SOD1 proteins are a pathological hallmark of SOD1-related fALS cases; however, the molecular mechanism of SOD1 aggregation remains controversial...

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Detalles Bibliográficos
Autor principal: Furukawa, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841916/
https://www.ncbi.nlm.nih.gov/pubmed/24348334
http://dx.doi.org/10.3389/fncel.2013.00240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841916/
https://www.ncbi.nlm.nih.gov/pubmed/24348334
http://dx.doi.org/10.3389/fncel.2013.00240

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