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Trichostatin A Stabilizes the Expression of Pluripotent Genes in Human Mesenchymal Stem Cells during Ex Vivo Expansion

BACKGROUND: Mesenchymal stem cells (MSCs) have been considered as ideal cells for the treatment of a variety of diseases. However, aging and spontaneous differentiation of MSCs during culture expansion dampen their effectiveness. Previous studies suggest that ex vivo aging of MSCs is largely caused...

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Detalles Bibliográficos
Autores principales: Han, Bing, Li, Jing, Li, Zhilong, Guo, Ling, Wang, Shan, Liu, Peishu, Wu, Yaojiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842316/
https://www.ncbi.nlm.nih.gov/pubmed/24312356
http://dx.doi.org/10.1371/journal.pone.0081781