Thrombin inhibits HMGB1-mediated proinflammatory signaling responses when endothelial protein C receptor is occupied by its natural ligand

High mobility group box 1 (HMGB1) is involved in the pathogenesis of vascular diseases. Unlike activated protein C (APC), the activation of PAR-1 by thrombin is known to elicit proinflammatory responses. To determine whether the occupancy of EPCR by the Gla-domain of APC is responsible for the PAR-1...

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Detalles Bibliográficos
Autores principales: Bae, Jong-Sup, Rezaie, Alireza R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842408/
https://www.ncbi.nlm.nih.gov/pubmed/24152910
http://dx.doi.org/10.5483/BMBRep.2013.46.11.056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842408/
https://www.ncbi.nlm.nih.gov/pubmed/24152910
http://dx.doi.org/10.5483/BMBRep.2013.46.11.056

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