Novel Functional Assay for Spindle-Assembly Checkpoint by Cyclin-Dependent Kinase Activity to Predict Taxane Chemosensitivity in Breast Tumor Patient

Taxanes are among the drugs most commonly used for preoperative chemotherapy for breast cancer. Taxanes induce mitotic arrest and subsequent apoptosis. The spindle-assembly checkpoint (SAC) is known to be activated during mitosis, along with cyclin-dependent kinase-1 (CDK1), and is required for taxa...

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Detalles Bibliográficos
Autores principales: Torikoshi, Yasuhiro, Gohda, Keigo, Davis, Michelle L., Symmans, W. Fraser, Pusztai, Lajos, Kazansky, Anna, Nakayama, Satoshi, Yoshida, Tomokazu, Matsushima, Tomoko, Hortobagyi, Gabriel N., Ishihara, Hideki, Kim, Seung Jin, Noguchi, Shinzaburo, Ueno, Naoto T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842438/
https://www.ncbi.nlm.nih.gov/pubmed/24312139
http://dx.doi.org/10.7150/jca.6248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842438/
https://www.ncbi.nlm.nih.gov/pubmed/24312139
http://dx.doi.org/10.7150/jca.6248

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