Hematopoietic Stem and Progenitor Cells Acquire Distinct DNA-Hypermethylation During in vitro Culture

Hematopoietic stem and progenitor cells (HPCs) can be maintained in vitro, but the vast majority of their progeny loses stemness during culture. In this study, we compared DNA-methylation (DNAm) profiles of freshly isolated and culture-expanded HPCs. Culture conditions of CD34(+) cells - either with...

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Detalles Bibliográficos
Autores principales: Weidner, Carola Ingrid, Walenda, Thomas, Lin, Qiong, Wölfler, Monika Martina, Denecke, Bernd, Costa, Ivan Gesteira, Zenke, Martin, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842544/
https://www.ncbi.nlm.nih.gov/pubmed/24284763
http://dx.doi.org/10.1038/srep03372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842544/
https://www.ncbi.nlm.nih.gov/pubmed/24284763
http://dx.doi.org/10.1038/srep03372

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