HIV relies on neddylation for ubiquitin ligase-mediated functions

BACKGROUND: HIV and SIV defeat antiviral proteins by usurping Cullin-RING E3 ubiquitin ligases (CRLs) and likely influence other cellular processes through these as well. HIV-2 viral protein X (Vpx) engages the cullin4-containing CRL4 complex to deplete the antiviral protein SAMHD1. Vif expressed by...

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Detalles Bibliográficos
Autores principales: Nekorchuk, Michael D, Sharifi, Hamayun J, Furuya, Andrea KM, Jellinger, Robert, de Noronha, Carlos MC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842660/
https://www.ncbi.nlm.nih.gov/pubmed/24245672
http://dx.doi.org/10.1186/1742-4690-10-138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842660/
https://www.ncbi.nlm.nih.gov/pubmed/24245672
http://dx.doi.org/10.1186/1742-4690-10-138

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