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HIV relies on neddylation for ubiquitin ligase-mediated functions

BACKGROUND: HIV and SIV defeat antiviral proteins by usurping Cullin-RING E3 ubiquitin ligases (CRLs) and likely influence other cellular processes through these as well. HIV-2 viral protein X (Vpx) engages the cullin4-containing CRL4 complex to deplete the antiviral protein SAMHD1. Vif expressed by...

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Detalles Bibliográficos
Autores principales:	Nekorchuk, Michael D, Sharifi, Hamayun J, Furuya, Andrea KM, Jellinger, Robert, de Noronha, Carlos MC
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842660/ https://www.ncbi.nlm.nih.gov/pubmed/24245672 http://dx.doi.org/10.1186/1742-4690-10-138

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