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Trace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation

BACKGROUND: Norleucine and norvaline belong to a group of non-canonical amino acids which are synthesized as byproducts in the branched chain amino acid metabolism of Escherichia coli. The earlier observed misincorporation of these rare amino acids into recombinant proteins has attracted increasing...

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Detalles Bibliográficos
Autores principales: Biermann, Michael, Linnemann, Julia, Knüpfer, Uwe, Vollstädt, Sebastian, Bardl, Bettina, Seidel, Guido, Horn, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842802/
https://www.ncbi.nlm.nih.gov/pubmed/24261588
http://dx.doi.org/10.1186/1475-2859-12-116